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KMID : 0363219920300060857
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Korean Journal of Dermatology
1992 Volume.30 No. 6 p.857 ~ p.863
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A Study of Skin Responses produced by Sodium Lauryl Sulfate and Ethanol, and Quantification of Erythema using a Chroma meter in Healthy Men
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Abstract
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Irritant skin reactions can be evaluated by several techniques. Using different scores for the degree of erythema, edema, scaling and fisssuring is the time-honored approach but implies the disadventages of lacking objectivity and parametric
properties.
This paper describes the objective measurement of irritant skin responses to various concentrations of Sodium Lauryl Sulfate (SLS) and Ethanol by a color reflectance meter (Chroma Meter) and compares with visual scoring
@ES The results are summarized as follows:
@EN 1. Pretreatment assessments by a Chroma Meter on normal forearm area showed an average score of 7.70±1.53 for chroma Meter value a (redness score).
2. Skin responses to SLS in various concentrations of 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 7.5% under occlusion for 24 hours were assessed by visual scoring system. They are measured 0.56±1.10, 0.74±1.29, 1.19±1.36, 2.11±1.69, 2.19±1.91,
2.56±1.50,
2.81±2.16 respec-tively.
3. Skin responses to SLS in various concentrations of 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 7.5% under occlusion for 24 hours were assessed by a Chroma Meter value a (redness score). They are measured 8.29±1.98, 8.37±2.47, 9.31±2.27, 10.34±2.97,
10.35±3.18, 10.51±2.47, 11.61±3.45 respectively.
4. Skin responses to Ethanol in various concentrations were nearly negligible.
5. We have demonstrated there is a highly significant correlation between skin redness measured by the Chroma Meter and visually assessed erythema (P<0.0001). It yields reproducible, objective, quantitative measurements of erythema that parallel
the
subjective visual assessments. (Kor J Dermatol 1992;30(6):857-863)
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